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Of those, 1,482 (37%) who initiated injectable semaglutide between March 2018 and November 2023 met all inclusion criteria: At least 2 semaglutide prescriptions 3 months apart (to be reasonably confident of ongoing use) No other GLP-1 receptor agonist within 6 months before semaglutide initiation or within the first 3 months of semaglutide use No prescription for oral semaglutide (Rybelsus) Baseline BMI 27 kg/m2, based on the most recent BMI measurement available within 6 months before (or on) the semaglutide start date At least 1 follow-up BMI measurement available 3-12 months after the semaglutide start date Among all weight measurements within up to 12 months after semaglutide initiation, BMI was calculated as weight in kilograms divided by the square of height in meters
These results together demonstrate efficient neuronal differentiation, validated across morphological and transcriptional levels
Interestingly, tri-agonists also show neuroprotective effects in rodent models of Alzheimer's disease and Parkinsons disease [241, 274,275,276,277,278,279,280,281]
Key Takeaways GLP-1 medications mimic the GLP-1 hormone your gut releases after eating
2025 Aug 28;16:100205
